A Comparison of Cephalexin with Fosfomycin Trometanol (monurol) in the treatment of pregnant women with lower urinary tract

• Main Authors: atoosa karimi, maryam Afrakhteh, afsane Aghazadeh Naeini, zohre amiri
• Format: Article
• Language: fas
• Published: Lorestan University of Medical Science 2012-03-01
• Series: Yafteh
• Subjects: Possetive urine culture; Pregnancy; Cephalexin; Fosfomycin Trometamol.
• Online Access: http://yafte.lums.ac.ir/browse.php?a_code=A-10-1-27&slc_lang=en&sid=1

Background : Because of the relation between bacteriuria in pregnancy and low birth weight and immaturity, a proper and suitable treatment is important. Fosfomycin Treometamol is one of the most safe drugs in pregnancy. This study was designed to compare it with Cephalexin. Materials and Methods: In this randomized clinical trial, 166 pregnant women with. positive urine culture (cfu >105) were randomized into two groups to receive Cephalexin and Fosfomycin. Urine cultures were repeated one week and one month after treatment. Results: The most bacteria in Cephalexin groups were E.coli (87.8%), Streptococcus (7.3%)< Proteus (2.4%) and Klebsiella (2.4%), and in the later group they were E.coli (84.5%), Streptococcus (9.5%)< Proteus (4.8%) and Klebsiella (1.2%) with no significant difference (p=0.737). After one week, success rate in Cephalexin group was 92.7% and for Fosfomycin was 91.7% (p=1). The odds ratio was 15.15 and relative risk was 1.01. All the cultures were negative after one month. 2 in the Cephalexin group and 3 in the Fosfomycin group had diarrhea (p=0.68). Conclusion: Considering the equality between Cephalexin and Fosfomycin, Fosfomycin can be used to treat uncomplicated bacteriuria in pregnancy.