A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis

A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis

<p>Abstract</p> <p>Background</p> <p>Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147, basigin) is an inducer of the expression of several matrix metalloproteinases (MMPs). We reported previously that blocking EMMPRIN activity reduced neuroinflammation and...

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Bibliographic Details
Main Authors: Agrawal Smriti M, Silva Claudia, Wang Janet, Tong Jade, Yong V
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Journal of Neuroinflammation
Subjects:
Experimental autoimmune encephalomyelitis
Extracellular matrix metalloproteinase inducer
Function-blocking antibody
Matrix metalloproteinases
Multiple sclerosis
Neuroinflammation T cell proliferation
Neurotoxicity
Online Access:http://www.jneuroinflammation.com/content/9/1/64

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