Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome
Patients with Cornelia de Lange Syndrome (CdLS) often have mutations in cohesin and its regulators; however, the molecular mechanism driving CdLS phenotypes is not well established. Here the authors reveal system skeletal organization genes are downregulated and show that cohesin and its loader Nipb...
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Bibliographic Details
| Main Authors: |
Patricia Garcia,
Rita Fernandez-Hernandez,
Ana Cuadrado,
Ignacio Coca,
Antonio Gomez,
Maria Maqueda,
Ana Latorre-Pellicer,
Beatriz Puisac,
Feliciano J. Ramos,
Juan Sandoval,
Manel Esteller,
Jose Luis Mosquera,
Jairo Rodriguez,
J. Pié,
Ana Losada,
Ethel Queralt |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-24808-z
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