In silico Analyses of Subtype Specific HIV-1 Tat-TAR RNA Interaction Reveals the Structural Determinants for Viral Activity

In silico Analyses of Subtype Specific HIV-1 Tat-TAR RNA Interaction Reveals the Structural Determinants for Viral Activity

HIV-1 Tat transactivates viral genes through strong interaction with TAR RNA. The stem-loop bulged region of TAR consisting of three nucleotides at the position 23–25 and the loop region consisting of six nucleotides at the position 30–35 are essential for viral transactivation. The arginine motif o...

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Bibliographic Details
Main Authors: Larance Ronsard, Tripti Rai, Devesh Rai, Vishnampettai G. Ramachandran, Akhil C. Banerjea
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Microbiology
Subjects:
HIV-1 Tat
transactivation
TAR RNA
genetic variations
molecular docking
hydrogen bond interaction
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01467/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01467/full

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