Titin-Actin Interaction: PEVK-Actin-Based Viscosity in a Large Animal

Titin-Actin Interaction: PEVK-Actin-Based Viscosity in a Large Animal

Titin exhibits an interaction between its PEVK segment and the actin filament resulting in viscosity, a speed dependent resistive force, which significantly influences diastolic filling in mice. While diastolic disease is clinically pervasive, humans express a more compliant titin (N2BA:N2B ratio ~...

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Bibliographic Details
Main Authors:	Charles S. Chung, Julius Bogomolovas, Alexander Gasch, Carlos G. Hidalgo, Siegfried Labeit, Henk L. Granzier
Format:	Article
Language:	English
Published:	Hindawi Limited 2011-01-01
Series:	Journal of Biomedicine and Biotechnology
Online Access:	http://dx.doi.org/10.1155/2011/310791

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