Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion

Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion

Abstract Background Parkinson’s disease (PD) is characterized by dopaminergic cell loss and inflammation in the substantia nigra (SN) leading to motor deficits but also to hippocampus-associated non-motor symptoms such as spatial learning and memory deficits. The cognitive decline is correlated with...

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Bibliographic Details
Main Authors: Elisabeth G. Hain, Maria Sparenberg, Justyna Rasińska, Charlotte Klein, Levent Akyüz, Barbara Steiner
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Neurogenesis
Inflammation
Neurodegeneration
Parkinson’s disease
Indomethacin
MPTP
Online Access:http://link.springer.com/article/10.1186/s12974-018-1179-4

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