Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway

Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway

Metabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease p...

Full description

Bibliographic Details
Main Authors: Jingbo Dai, Qiyuan Zhou, Jiwang Chen, Megan L. Rexius-Hall, Jalees Rehman, Guofei Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06376-x
id doaj-1fe0c5edcc05495a850007b6679a029b
record_format Article
spelling doaj-1fe0c5edcc05495a850007b6679a029b2021-05-11T10:33:46ZengNature Publishing GroupNature Communications2041-17232018-09-019111610.1038/s41467-018-06376-xAlpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathwayJingbo Dai0Qiyuan Zhou1Jiwang Chen2Megan L. Rexius-Hall3Jalees Rehman4Guofei Zhou5Department of Pediatrics, University of Illinois at ChicagoDepartment of Pediatrics, University of Illinois at ChicagoDivision of Pulmonary, Critical Care Medicine, Sleep and Allergy, Department of Medicine, University of Illinois at ChicagoDepartment of Bioengineering, University of Illinois at ChicagoDepartment of Bioengineering, University of Illinois at ChicagoDepartment of Pediatrics, University of Illinois at ChicagoMetabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease progression in animal models of PAH.https://doi.org/10.1038/s41467-018-06376-x
collection DOAJ
language English
format Article
sources DOAJ
author Jingbo Dai
Qiyuan Zhou
Jiwang Chen
Megan L. Rexius-Hall
Jalees Rehman
Guofei Zhou
spellingShingle Jingbo Dai
Qiyuan Zhou
Jiwang Chen
Megan L. Rexius-Hall
Jalees Rehman
Guofei Zhou
Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
Nature Communications
author_facet Jingbo Dai
Qiyuan Zhou
Jiwang Chen
Megan L. Rexius-Hall
Jalees Rehman
Guofei Zhou
author_sort Jingbo Dai
title Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_short Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_full Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_fullStr Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_full_unstemmed Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
title_sort alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the ampk-akt pathway
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Metabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease progression in animal models of PAH.
url https://doi.org/10.1038/s41467-018-06376-x
work_keys_str_mv AT jingbodai alphaenolaseregulatesthemalignantphenotypeofpulmonaryarterysmoothmusclecellsviatheampkaktpathway
AT qiyuanzhou alphaenolaseregulatesthemalignantphenotypeofpulmonaryarterysmoothmusclecellsviatheampkaktpathway
AT jiwangchen alphaenolaseregulatesthemalignantphenotypeofpulmonaryarterysmoothmusclecellsviatheampkaktpathway
AT meganlrexiushall alphaenolaseregulatesthemalignantphenotypeofpulmonaryarterysmoothmusclecellsviatheampkaktpathway
AT jaleesrehman alphaenolaseregulatesthemalignantphenotypeofpulmonaryarterysmoothmusclecellsviatheampkaktpathway
AT guofeizhou alphaenolaseregulatesthemalignantphenotypeofpulmonaryarterysmoothmusclecellsviatheampkaktpathway
_version_ 1721447918243676160

Similar Items