Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles

In many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well...

Full description

Bibliographic Details
Main Authors: A.J. Sojahrood, H. Haghi, R. Karshafian, M.C. Kolios
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Ultrasonics Sonochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1350417720317090
id doaj-1fd0b19f256946c59440dd5badbd9e03
record_format Article
spelling doaj-1fd0b19f256946c59440dd5badbd9e032021-03-13T04:21:46ZengElsevierUltrasonics Sonochemistry1350-41772021-04-0172105405Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubblesA.J. Sojahrood0H. Haghi1R. Karshafian2M.C. Kolios3Department of Physics, Ryerson University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Michael’s Hospital, Toronto, Ontario, Canada; Corresponding author.Department of Physics, Ryerson University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Michael’s Hospital, Toronto, Ontario, CanadaDepartment of Physics, Ryerson University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Michael’s Hospital, Toronto, Ontario, CanadaDepartment of Physics, Ryerson University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Michael’s Hospital, Toronto, Ontario, CanadaIn many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well understood. Here, we investigate the nonlinear behavior of the LCMBs by analyzing their bifurcation structure as a function of acoustic pressure. We show that, the LC can enhance the generation of period 2 (P2), P3, higher order subharmonics (SH), superharmonics and chaos at very low excitation pressures (e.g. 1 kPa). For LCMBs sonicated by their SH resonance frequency and in line with experimental observations with increasing pressure, P2 oscillations exhibit three stages: generation at low acoustic pressures, disappearance and re-generation. Within non-destructive oscillation regimes and by pressure amplitude increase, LCMBs can also exhibit two saddle node (SN) bifurcations resulting in possible abrupt enhancement of the scattered pressure. The first SN resembles the pressure dependent resonance phenomenon in uncoated MBs and the second SN resembles the pressure dependent SH resonance. Depending on the initial surface tension of the LCMBs, the nonlinear behavior may also be suppressed for a wide range of excitation pressures.http://www.sciencedirect.com/science/article/pii/S1350417720317090
collection DOAJ
language English
format Article
sources DOAJ
author A.J. Sojahrood
H. Haghi
R. Karshafian
M.C. Kolios
spellingShingle A.J. Sojahrood
H. Haghi
R. Karshafian
M.C. Kolios
Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
Ultrasonics Sonochemistry
author_facet A.J. Sojahrood
H. Haghi
R. Karshafian
M.C. Kolios
author_sort A.J. Sojahrood
title Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_short Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_full Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_fullStr Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_full_unstemmed Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
title_sort nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
publisher Elsevier
series Ultrasonics Sonochemistry
issn 1350-4177
publishDate 2021-04-01
description In many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well understood. Here, we investigate the nonlinear behavior of the LCMBs by analyzing their bifurcation structure as a function of acoustic pressure. We show that, the LC can enhance the generation of period 2 (P2), P3, higher order subharmonics (SH), superharmonics and chaos at very low excitation pressures (e.g. 1 kPa). For LCMBs sonicated by their SH resonance frequency and in line with experimental observations with increasing pressure, P2 oscillations exhibit three stages: generation at low acoustic pressures, disappearance and re-generation. Within non-destructive oscillation regimes and by pressure amplitude increase, LCMBs can also exhibit two saddle node (SN) bifurcations resulting in possible abrupt enhancement of the scattered pressure. The first SN resembles the pressure dependent resonance phenomenon in uncoated MBs and the second SN resembles the pressure dependent SH resonance. Depending on the initial surface tension of the LCMBs, the nonlinear behavior may also be suppressed for a wide range of excitation pressures.
url http://www.sciencedirect.com/science/article/pii/S1350417720317090
work_keys_str_mv AT ajsojahrood nonlineardynamicsandbifurcationstructureofultrasonicallyexcitedlipidcoatedmicrobubbles
AT hhaghi nonlineardynamicsandbifurcationstructureofultrasonicallyexcitedlipidcoatedmicrobubbles
AT rkarshafian nonlineardynamicsandbifurcationstructureofultrasonicallyexcitedlipidcoatedmicrobubbles
AT mckolios nonlineardynamicsandbifurcationstructureofultrasonicallyexcitedlipidcoatedmicrobubbles
_version_ 1724222259996917760