Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles
In many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-04-01
|
Series: | Ultrasonics Sonochemistry |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417720317090 |
id |
doaj-1fd0b19f256946c59440dd5badbd9e03 |
---|---|
record_format |
Article |
spelling |
doaj-1fd0b19f256946c59440dd5badbd9e032021-03-13T04:21:46ZengElsevierUltrasonics Sonochemistry1350-41772021-04-0172105405Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubblesA.J. Sojahrood0H. Haghi1R. Karshafian2M.C. Kolios3Department of Physics, Ryerson University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Michael’s Hospital, Toronto, Ontario, Canada; Corresponding author.Department of Physics, Ryerson University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Michael’s Hospital, Toronto, Ontario, CanadaDepartment of Physics, Ryerson University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Michael’s Hospital, Toronto, Ontario, CanadaDepartment of Physics, Ryerson University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Michael’s Hospital, Toronto, Ontario, CanadaIn many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well understood. Here, we investigate the nonlinear behavior of the LCMBs by analyzing their bifurcation structure as a function of acoustic pressure. We show that, the LC can enhance the generation of period 2 (P2), P3, higher order subharmonics (SH), superharmonics and chaos at very low excitation pressures (e.g. 1 kPa). For LCMBs sonicated by their SH resonance frequency and in line with experimental observations with increasing pressure, P2 oscillations exhibit three stages: generation at low acoustic pressures, disappearance and re-generation. Within non-destructive oscillation regimes and by pressure amplitude increase, LCMBs can also exhibit two saddle node (SN) bifurcations resulting in possible abrupt enhancement of the scattered pressure. The first SN resembles the pressure dependent resonance phenomenon in uncoated MBs and the second SN resembles the pressure dependent SH resonance. Depending on the initial surface tension of the LCMBs, the nonlinear behavior may also be suppressed for a wide range of excitation pressures.http://www.sciencedirect.com/science/article/pii/S1350417720317090 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A.J. Sojahrood H. Haghi R. Karshafian M.C. Kolios |
spellingShingle |
A.J. Sojahrood H. Haghi R. Karshafian M.C. Kolios Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles Ultrasonics Sonochemistry |
author_facet |
A.J. Sojahrood H. Haghi R. Karshafian M.C. Kolios |
author_sort |
A.J. Sojahrood |
title |
Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles |
title_short |
Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles |
title_full |
Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles |
title_fullStr |
Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles |
title_full_unstemmed |
Nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles |
title_sort |
nonlinear dynamics and bifurcation structure of ultrasonically excited lipid coated microbubbles |
publisher |
Elsevier |
series |
Ultrasonics Sonochemistry |
issn |
1350-4177 |
publishDate |
2021-04-01 |
description |
In many applications, microbubbles (MBs) are encapsulated by a lipid coating to increase their stability. However, the complex behavior of the lipid coating including buckling and rupture sophisticates the dynamics of the MBs and as a result the dynamics of the lipid coated MBs (LCMBs) are not well understood. Here, we investigate the nonlinear behavior of the LCMBs by analyzing their bifurcation structure as a function of acoustic pressure. We show that, the LC can enhance the generation of period 2 (P2), P3, higher order subharmonics (SH), superharmonics and chaos at very low excitation pressures (e.g. 1 kPa). For LCMBs sonicated by their SH resonance frequency and in line with experimental observations with increasing pressure, P2 oscillations exhibit three stages: generation at low acoustic pressures, disappearance and re-generation. Within non-destructive oscillation regimes and by pressure amplitude increase, LCMBs can also exhibit two saddle node (SN) bifurcations resulting in possible abrupt enhancement of the scattered pressure. The first SN resembles the pressure dependent resonance phenomenon in uncoated MBs and the second SN resembles the pressure dependent SH resonance. Depending on the initial surface tension of the LCMBs, the nonlinear behavior may also be suppressed for a wide range of excitation pressures. |
url |
http://www.sciencedirect.com/science/article/pii/S1350417720317090 |
work_keys_str_mv |
AT ajsojahrood nonlineardynamicsandbifurcationstructureofultrasonicallyexcitedlipidcoatedmicrobubbles AT hhaghi nonlineardynamicsandbifurcationstructureofultrasonicallyexcitedlipidcoatedmicrobubbles AT rkarshafian nonlineardynamicsandbifurcationstructureofultrasonicallyexcitedlipidcoatedmicrobubbles AT mckolios nonlineardynamicsandbifurcationstructureofultrasonicallyexcitedlipidcoatedmicrobubbles |
_version_ |
1724222259996917760 |