Mast Cell Coupling to the Kallikrein–Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease

Mast Cell Coupling to the Kallikrein–Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease

During the course of Chagas disease, infectious forms of Trypanosoma cruzi are occasionally liberated from parasitized heart cells. Studies performed with tissue culture trypomastigotes (TCTs, Dm28c strain) demonstrated that these parasites evoke neutrophil/CXCR2-dependent microvascular leakage by a...

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Bibliographic Details
Main Authors: Clarissa R. Nascimento, Daniele Andrade, Carla Eponina Carvalho-Pinto, Rafaela Rangel Serra, Lucas Vellasco, Guilherme Brasil, Erivan Schnaider Ramos-Junior, Julia Barbalho da Mota, Larissa Nogueira Almeida, Marcus V. Andrade, Maria de Nazaré Correia Soeiro, Luiz Juliano, Patrícia Hessab Alvarenga, Ana Carolina Oliveira, Fernando Lencastre Sicuro, Antônio C. Campos de Carvalho, Erik Svensjö, Julio Scharfstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
bradykinin
Chagas disease
endothelin
G protein-coupled receptors
kallikrein
mast cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00840/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00840/full

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