Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding

Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding

Since the beginning of 2019, the Hoogendoorn lab is active at the University of Geneva. We are a Chemical Biology lab and our research focuses on the Hedgehog (Hh) signalling pathway and the primary cilium, a small cellular organelle which corrects structure and function, is required to conduct the...

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Main Author: Sascha Hoogendoorn
Format: Article
Language:deu
Published: Swiss Chemical Society 2020-09-01
Series:CHIMIA
Subjects:
chemical biology
hedgehog signalling
phenotypic screens
small-molecule probes
target identification
Online Access:https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000009/art00002
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spelling doaj-1fca3ca3a3464e2a84b618b01986941e2020-11-25T03:40:49ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242020-09-0174965265810.2533/chimia.2020.652Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic UnderstandingSascha Hoogendoorn0University of Geneva, Department of Organic Chemistry, NCCR Chemical Biology, Quai Ernest-Ansermet 30, CH-1211 Gèneve, SwitzerlandSince the beginning of 2019, the Hoogendoorn lab is active at the University of Geneva. We are a Chemical Biology lab and our research focuses on the Hedgehog (Hh) signalling pathway and the primary cilium, a small cellular organelle which corrects structure and function, is required to conduct the Hh signal. Ciliary Hh signalling plays an important role in embryonic development, and its dysregulation consequently results in developmental disorders as well as a variety of cancers. We use an interdisciplinary approach, ranging from organic chemistry to cell biology and genetics, to develop chemical tools to study and perturb ciliary signalling. In this account, I will highlight existing small molecules that target the Hh pathway, our efforts to discover new compounds, and the methodologies that we employ for target deconvolution and mechanism of action studies.https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000009/art00002chemical biologyhedgehog signallingphenotypic screenssmall-molecule probestarget identification
collection DOAJ
language deu
format Article
sources DOAJ
author Sascha Hoogendoorn
spellingShingle Sascha Hoogendoorn
Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding
CHIMIA
chemical biology
hedgehog signalling
phenotypic screens
small-molecule probes
target identification
author_facet Sascha Hoogendoorn
author_sort Sascha Hoogendoorn
title Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding
title_short Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding
title_full Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding
title_fullStr Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding
title_full_unstemmed Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding
title_sort small molecules targeting the hedgehog pathway: from phenotype to mechanistic understanding
publisher Swiss Chemical Society
series CHIMIA
issn 0009-4293
2673-2424
publishDate 2020-09-01
description Since the beginning of 2019, the Hoogendoorn lab is active at the University of Geneva. We are a Chemical Biology lab and our research focuses on the Hedgehog (Hh) signalling pathway and the primary cilium, a small cellular organelle which corrects structure and function, is required to conduct the Hh signal. Ciliary Hh signalling plays an important role in embryonic development, and its dysregulation consequently results in developmental disorders as well as a variety of cancers. We use an interdisciplinary approach, ranging from organic chemistry to cell biology and genetics, to develop chemical tools to study and perturb ciliary signalling. In this account, I will highlight existing small molecules that target the Hh pathway, our efforts to discover new compounds, and the methodologies that we employ for target deconvolution and mechanism of action studies.
topic chemical biology
hedgehog signalling
phenotypic screens
small-molecule probes
target identification
url https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000009/art00002
work_keys_str_mv AT saschahoogendoorn smallmoleculestargetingthehedgehogpathwayfromphenotypetomechanisticunderstanding
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