Validation of Functional Assessment of Cancer Therapy with Nasopharyngeal Cancer Subscale (FACT-NP) for Quality of Life in Thai Patients

• Main Authors: Thanarpan Peerawong, Chanon Kongkamol, Zhiping Chen, Paytai Rordlamool, Duangjai Sangtawan, Rungarun Jiratrachu
• Format: Article
• Language: English
• Published: Prince of Songkla University 2019-07-01
• Series: Journal of Health Science and Medical Research (JHSMR)
• Subjects: fact-np; factor analysis; nasopharyngeal cancer; quality of life
• Online Access: https://www.jhsmr.org/index.php/jhsmr/article/view/58
• ISSN: 2586-9981; 2630-0559

Objective: To develop and validate the Thai version of the functional assessment of cancer therapy with nasopharyngeal cancer subscale (FACT-NP) with the abbreviated version of the World Health Organization Quality of Life-BREF instrument (WHOQOL-BREF). Material and Methods: A cross-sectional study was performed in the Radiology Department between January 2014 and October 2016. Inclusion criteria: nasopharyngeal carcinoma patients aged greater than 18 years. Exclusion criteria: no comprehension of the Thai language, had other cancers (except for skin cancer and diagnosed with impaired cognition and/or overt psychosis), major depression or delirium. After signing the consent form, participants were interviewed and self-completed FACT-NP and WHOQOL-BREF. The structure of the FACT-NP was determined with exploratory factors analysis. The internal reliability of identified domains was evaluated using Cronbach’s alpha. The correlation between domains of the modified FACT-NP and the domains of WHOQOL-BREF were examined with Spearman’s correlation. Known-group validity was determined by comparing patients with different sociodemographic and clinical characteristics using the T-test, Ranksum test and analysis of variance. A p-value of less than 0.05 was considered significant. Results: This study was terminated early due to a long accrual period. Of the 230 patients included in the study, only 220 completed both FACT-NP and WHOQOL-BREF. Exploratory factor analysis showed an accumulative variance of 0.56 with 4 factors. The internal reliability of modified FACT-NP was 0.92. There was moderate correlation between modified FACT-NP and WHOQOL-BREF. Both the modified FACT-NP and WHOQOL-BREF could identify differences between the groups. Conclusion: The Thai modified FACT-NP was found to be both valid and reliable for measuring the quality of life in Thai nasopharyngeal cancer patients.