CSF1/CSF1R Axis Blockade Limits Mesothelioma and Enhances Efficiency of Anti-PDL1 Immunotherapy

CSF1/CSF1R Axis Blockade Limits Mesothelioma and Enhances Efficiency of Anti-PDL1 Immunotherapy

Colony-Stimulating Factor 1 (CSF1)/Colony-Stimulating Factor Receptor 1 (CSF1R) signaling orchestrates tumor-associated macrophage (TAM) recruitment and polarization towards a pro-tumor M2 phenotype, the dominant phenotype of TAMs infiltrating mesothelioma tumors. We hypothesized that CSF1/CSF1R inh...

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Bibliographic Details
Main Authors: Sophia Fotiou Magkouta, Photene Christou Vaitsi, Apostolos Georgiou Pappas, Marianthi Iliopoulou, Chrysavgi Nikolaou Kosti, Katherina Psarra, Ioannis Theodorou Kalomenidis
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
mesothelioma
immunotherapy
CSF1R
macrophages
Online Access:https://www.mdpi.com/2072-6694/13/11/2546

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