Cardiac troponin I R193H mutant interacts with HDAC1 to repress phosphodiesterase 4D expression in cardiomyocytes

Cardiac troponin I R193H mutant interacts with HDAC1 to repress phosphodiesterase 4D expression in cardiomyocytes

Cardiac Troponin I (cTnI) is a subunit of the thin filament involved in regulation of heart contraction. Mutated cTnI accounts for most genetic mutations associated with restrictive cardiomyopathy (RCM). We previously found phosphodiesterase 4D (PDE4D) decreased in RCM mice with cTnIR193H mutation a...

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Bibliographic Details
Main Authors: Weian Zhao, Qian lu, Jing Luo, Bo Pan, Ling-Juan Liu, Jie Tian
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Genes and Diseases
Subjects:
cTnIR93H
EGCG
HDAC1
Histone modifications
PDE4D reduction
Online Access:http://www.sciencedirect.com/science/article/pii/S235230422030012X

Internet

http://www.sciencedirect.com/science/article/pii/S235230422030012X

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