Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development

Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development

SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation cau...

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Main Authors: Jeremie Vitte, Fuying Gao, Giovanni Coppola, Alexander R. Judkins, Marco Giovannini
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00346-5
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spelling doaj-1faf2971b5a4423bb8a856e7f90310eb2021-01-31T12:48:47ZengNature Publishing GroupNature Communications2041-17232017-08-018111310.1038/s41467-017-00346-5Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor developmentJeremie Vitte0Fuying Gao1Giovanni Coppola2Alexander R. Judkins3Marco Giovannini4Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California Los AngelesSemel Institute for Neuroscience & Human Behavior and Department of Psychiatry and Biobehavioral Sciences, University of California Los AngelesSemel Institute for Neuroscience & Human Behavior and Department of Psychiatry and Biobehavioral Sciences, University of California Los AngelesDepartment of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern CaliforniaDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California Los AngelesSMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.https://doi.org/10.1038/s41467-017-00346-5
collection DOAJ
language English
format Article
sources DOAJ
author Jeremie Vitte
Fuying Gao
Giovanni Coppola
Alexander R. Judkins
Marco Giovannini
spellingShingle Jeremie Vitte
Fuying Gao
Giovanni Coppola
Alexander R. Judkins
Marco Giovannini
Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
Nature Communications
author_facet Jeremie Vitte
Fuying Gao
Giovanni Coppola
Alexander R. Judkins
Marco Giovannini
author_sort Jeremie Vitte
title Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_short Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_full Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_fullStr Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_full_unstemmed Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
title_sort timing of smarcb1 and nf2 inactivation determines schwannoma versus rhabdoid tumor development
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.
url https://doi.org/10.1038/s41467-017-00346-5
work_keys_str_mv AT jeremievitte timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment
AT fuyinggao timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment
AT giovannicoppola timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment
AT alexanderrjudkins timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment
AT marcogiovannini timingofsmarcb1andnf2inactivationdeterminesschwannomaversusrhabdoidtumordevelopment
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