Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells

Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells

Sphingolipids are not only important components of membranes but also have functions in protein trafficking and intracellular signaling. The LCB1 gene encodes a subunit of the serine palmitoyltransferase, which is responsible for the first step of sphingolipid synthesis. Here, we show that activatio...

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Bibliographic Details
Main Authors: Sharon Epstein, Clare L. Kirkpatrick, Guillaume A. Castillon, Manuel Muñiz, Isabelle Riezman, Fabrice P.A. David, Claes B. Wollheim, Howard Riezman
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Journal of Lipid Research
Subjects:
sphingolipids
serine palmitoyltransferase
endoplasmic reticulum stress
CerS6
fatty acid hydroxylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520413562

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