Enhanced Stability of Detergent-Free Human Native STEAP1 Protein from Neoplastic Prostate Cancer Cells upon an Innovative Isolation Procedure

Enhanced Stability of Detergent-Free Human Native STEAP1 Protein from Neoplastic Prostate Cancer Cells upon an Innovative Isolation Procedure

Background: The STEAP1 is a cell-surface antigen over-expressed in prostate cancer, which contributes to tumor progression and aggressiveness. However, the molecular mechanisms underlying STEAP1 and its structural determinants remain elusive. Methods: The fraction capacity of Butyl- and Octyl-Sephar...

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Bibliographic Details
Main Authors: Jorge Barroca-Ferreira, Pedro Cruz-Vicente, Marino F. A. Santos, Sandra M. Rocha, Teresa Santos-Silva, Cláudio J. Maia, Luís A. Passarinha
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
circular dichroism
co-immunoprecipitation
prostate cancer
protein purification
STEAP1
thermal stability
Online Access:https://www.mdpi.com/1422-0067/22/18/10012

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