Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbits without increasing the risk of bleeding.
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Nature Publishing Group
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17648-w |
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doaj-1f9ddb75be1e4a398c1ff63698dcaa1b2021-08-08T11:38:57ZengNature Publishing GroupNature Communications2041-17232020-08-0111111310.1038/s41467-020-17648-wCyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungsJonas Wilbs0Xu-Dong Kong1Simon J. Middendorp2Raja Prince3Alida Cooke4Caitlin T. Demarest5Mai M. Abdelhafez6Kalliope Roberts7Nao Umei8Patrick Gonschorek9Christina Lamers10Kaycie Deyle11Robert Rieben12Keith E. Cook13Anne Angelillo-Scherrer14Christian Heinis15Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of BernDepartment of Biomedical Engineering, Carnegie Mellon UniversityDepartment of Biomedical Engineering, Carnegie Mellon UniversityDepartment of Clinical Research, University of BernDepartment of Biomedical Engineering, Carnegie Mellon UniversityDepartment of Biomedical Engineering, Carnegie Mellon UniversityInstitute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Department of Clinical Research, University of BernDepartment of Biomedical Engineering, Carnegie Mellon UniversityDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of BernInstitute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbits without increasing the risk of bleeding.https://doi.org/10.1038/s41467-020-17648-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jonas Wilbs Xu-Dong Kong Simon J. Middendorp Raja Prince Alida Cooke Caitlin T. Demarest Mai M. Abdelhafez Kalliope Roberts Nao Umei Patrick Gonschorek Christina Lamers Kaycie Deyle Robert Rieben Keith E. Cook Anne Angelillo-Scherrer Christian Heinis |
| spellingShingle |
Jonas Wilbs Xu-Dong Kong Simon J. Middendorp Raja Prince Alida Cooke Caitlin T. Demarest Mai M. Abdelhafez Kalliope Roberts Nao Umei Patrick Gonschorek Christina Lamers Kaycie Deyle Robert Rieben Keith E. Cook Anne Angelillo-Scherrer Christian Heinis Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs Nature Communications |
| author_facet |
Jonas Wilbs Xu-Dong Kong Simon J. Middendorp Raja Prince Alida Cooke Caitlin T. Demarest Mai M. Abdelhafez Kalliope Roberts Nao Umei Patrick Gonschorek Christina Lamers Kaycie Deyle Robert Rieben Keith E. Cook Anne Angelillo-Scherrer Christian Heinis |
| author_sort |
Jonas Wilbs |
| title |
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs |
| title_short |
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs |
| title_full |
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs |
| title_fullStr |
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs |
| title_full_unstemmed |
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs |
| title_sort |
cyclic peptide fxii inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-08-01 |
| description |
Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbits without increasing the risk of bleeding. |
| url |
https://doi.org/10.1038/s41467-020-17648-w |
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