Matching Mitochondrial DNA Haplotypes for Circumventing Tissue-Specific Segregation Bias

Matching Mitochondrial DNA Haplotypes for Circumventing Tissue-Specific Segregation Bias

Summary: Mitochondrial DNA (mtDNA) segregation associated with donor-recipient mtDNA mismatch in mitochondria replacement therapy leads to unknown risks. Here, to explore whether matching mtDNA haplotypes contributes to ameliorating segregation, we reproduced various degrees of heteroplasmic mice wi...

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Bibliographic Details
Main Authors:	Jianxin Pan, Li Wang, Charles Lu, Yanming Zhu, Zhunyuan Min, Xi Dong, Hongying Sha
Format:	Article
Language:	English
Published:	Elsevier 2019-03-01
Series:	iScience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004219300689

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