Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling

Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling

The chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis f...

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Main Authors: Maximilian Stangier, Antonis M. Messinis, João C. A. Oliveira, Hao Yu, Lutz Ackermann
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25005-8
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spelling doaj-1f96bb1f461540d38bee6aeed5f4505e2021-08-08T11:37:24ZengNature Publishing GroupNature Communications2041-17232021-08-011211810.1038/s41467-021-25005-8Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labelingMaximilian Stangier0Antonis M. Messinis1João C. A. Oliveira2Hao Yu3Lutz Ackermann4Institute for Organic and Biomolecular Chemistry, Georg-August-Universität GöttingenInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität GöttingenInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität GöttingenInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität GöttingenInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität GöttingenThe chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis for late-stage peptide diversification.https://doi.org/10.1038/s41467-021-25005-8
collection DOAJ
language English
format Article
sources DOAJ
author Maximilian Stangier
Antonis M. Messinis
João C. A. Oliveira
Hao Yu
Lutz Ackermann
spellingShingle Maximilian Stangier
Antonis M. Messinis
João C. A. Oliveira
Hao Yu
Lutz Ackermann
Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
Nature Communications
author_facet Maximilian Stangier
Antonis M. Messinis
João C. A. Oliveira
Hao Yu
Lutz Ackermann
author_sort Maximilian Stangier
title Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_short Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_full Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_fullStr Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_full_unstemmed Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling
title_sort rhodaelectro-catalyzed access to chromones via formyl c–h activation towards peptide electro-labeling
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-08-01
description The chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis for late-stage peptide diversification.
url https://doi.org/10.1038/s41467-021-25005-8
work_keys_str_mv AT maximilianstangier rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling
AT antonismmessinis rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling
AT joaocaoliveira rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling
AT haoyu rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling
AT lutzackermann rhodaelectrocatalyzedaccesstochromonesviaformylchactivationtowardspeptideelectrolabeling
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