Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis

Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis

Amyloidosis is characterized by extracellular deposition of protein fibrils of chemically heterogeneous composition. Early recognition and identification of amyloid deposits allows an early start of therapy, which may entail a better prognosis. Congo red staining according to Romhányi (1971) is a hi...

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Main Author: M. Bély
Format: Article
Language:English
Published: Hindawi Limited 2006-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2006.35
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spelling doaj-1f93dc30d6fe4cc6a43c8615bd8d89b02020-11-24T21:34:39ZengHindawi LimitedThe Scientific World Journal1537-744X2006-01-01615416810.1100/tsw.2006.35Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and AmyloidosisM. Bély0Department of Pathology, Policlinic of the Hospitaller Brothers of St. John of God at Budapest, Frankel Leo Street 17-19, Budapest, HungaryAmyloidosis is characterized by extracellular deposition of protein fibrils of chemically heterogeneous composition. Early recognition and identification of amyloid deposits allows an early start of therapy, which may entail a better prognosis. Congo red staining according to Romhányi (1971) is a highly specific and sensitive method for early microscopic recognition of amyloidosis. The main and most important types of amyloidosis may be distinguished by classic histochemical methods of performate pretreatment according to Romhányi (1979), or by KMnO4 oxidation according to Wright (1977) followed by Congo red staining and viewed under polarized light. Differences in the speed of breakdown (disintegration) of amyloid deposits according to Bély and Apáthy allow a more precise distinction of various types of amyloid.http://dx.doi.org/10.1100/tsw.2006.35
collection DOAJ
language English
format Article
sources DOAJ
author M. Bély
spellingShingle M. Bély
Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis
The Scientific World Journal
author_facet M. Bély
author_sort M. Bély
title Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis
title_short Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis
title_full Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis
title_fullStr Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis
title_full_unstemmed Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis
title_sort histochemical differential diagnosis and polarization optical analysis of amyloid and amyloidosis
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2006-01-01
description Amyloidosis is characterized by extracellular deposition of protein fibrils of chemically heterogeneous composition. Early recognition and identification of amyloid deposits allows an early start of therapy, which may entail a better prognosis. Congo red staining according to Romhányi (1971) is a highly specific and sensitive method for early microscopic recognition of amyloidosis. The main and most important types of amyloidosis may be distinguished by classic histochemical methods of performate pretreatment according to Romhányi (1979), or by KMnO4 oxidation according to Wright (1977) followed by Congo red staining and viewed under polarized light. Differences in the speed of breakdown (disintegration) of amyloid deposits according to Bély and Apáthy allow a more precise distinction of various types of amyloid.
url http://dx.doi.org/10.1100/tsw.2006.35
work_keys_str_mv AT mbely histochemicaldifferentialdiagnosisandpolarizationopticalanalysisofamyloidandamyloidosis
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