Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil

Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil

MonolixSuite is a software widely used for model‐based drug development. It contains interconnected applications for data visualization, noncompartmental analysis, nonlinear mixed effect modeling, and clinical trial simulations. Its main assets are ease of use via an interactive graphical interface,...

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Main Authors: Pauline Traynard, Géraldine Ayral, Monika Twarogowska, Jonathan Chauvin
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12500
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spelling doaj-1f8dfddbac4a4174aed811f2082139aa2020-11-25T03:37:51ZengWileyCPT: Pharmacometrics & Systems Pharmacology2163-83062020-04-019419821010.1002/psp4.12500Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of RemifentanilPauline Traynard0Géraldine Ayral1Monika Twarogowska2Jonathan Chauvin3Lixoft Antony FranceLixoft Antony FranceLixoft Antony FranceLixoft Antony FranceMonolixSuite is a software widely used for model‐based drug development. It contains interconnected applications for data visualization, noncompartmental analysis, nonlinear mixed effect modeling, and clinical trial simulations. Its main assets are ease of use via an interactive graphical interface, computation speed, and efficient parameter estimation even for complex models. This tutorial presents a step‐by‐step pharmacokinetic (PK) modeling workflow using MonolixSuite, including how to visualize the data, set up a population PK model, estimate parameters, and diagnose and improve the model incrementally.https://doi.org/10.1002/psp4.12500
collection DOAJ
language English
format Article
sources DOAJ
author Pauline Traynard
Géraldine Ayral
Monika Twarogowska
Jonathan Chauvin
spellingShingle Pauline Traynard
Géraldine Ayral
Monika Twarogowska
Jonathan Chauvin
Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil
CPT: Pharmacometrics & Systems Pharmacology
author_facet Pauline Traynard
Géraldine Ayral
Monika Twarogowska
Jonathan Chauvin
author_sort Pauline Traynard
title Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil
title_short Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil
title_full Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil
title_fullStr Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil
title_full_unstemmed Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil
title_sort efficient pharmacokinetic modeling workflow with the monolixsuite: a case study of remifentanil
publisher Wiley
series CPT: Pharmacometrics & Systems Pharmacology
issn 2163-8306
publishDate 2020-04-01
description MonolixSuite is a software widely used for model‐based drug development. It contains interconnected applications for data visualization, noncompartmental analysis, nonlinear mixed effect modeling, and clinical trial simulations. Its main assets are ease of use via an interactive graphical interface, computation speed, and efficient parameter estimation even for complex models. This tutorial presents a step‐by‐step pharmacokinetic (PK) modeling workflow using MonolixSuite, including how to visualize the data, set up a population PK model, estimate parameters, and diagnose and improve the model incrementally.
url https://doi.org/10.1002/psp4.12500
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AT monikatwarogowska efficientpharmacokineticmodelingworkflowwiththemonolixsuiteacasestudyofremifentanil
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