BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain.

BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain.

BIG1, an activator protein of the small GTPase, Arf, and encoded by the Arfgef1 gene, is one of candidate genes for epileptic encephalopathy. To know the involvement of BIG1 in epileptic encephalopathy, we analyzed BIG1-deficient mice and found that BIG1 regulates neurite outgrowth and brain develop...

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Bibliographic Details
Main Authors: Jia-Jie Teoh, Tomohiko Iwano, Masataka Kunii, Nur Atik, Erda Avriyanti, Shin-Ichiro Yoshimura, Kenta Moriwaki, Akihiro Harada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5393877?pdf=render

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http://europepmc.org/articles/PMC5393877?pdf=render

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