Molecular Insights into the Mechanism of Necroptosis: The Necrosome As a Potential Therapeutic Target

Molecular Insights into the Mechanism of Necroptosis: The Necrosome As a Potential Therapeutic Target

Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and vascularization. It plays important roles in various pathological processes, including neurodegeneration, inflammatory...

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Bibliographic Details
Main Authors: Jing Chen, Renate Kos, Johan Garssen, Frank Redegeld
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
necroptosis
mlkl
rip kinase
necrosome
programmed cell death
cancer
inflammatory diseases
Online Access:https://www.mdpi.com/2073-4409/8/12/1486

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