Structure-Functional Analysis of Human Cytochrome P450 2C8 Using Directed Evolution

The human genome includes four cytochrome P450 2C subfamily enzymes, and CYP2C8 has generated research interest because it is subject to drug–drug interactions and various polymorphic outcomes. To address the structure-functional complexity of CYP2C8, its catalytic activity was studied using a direc...

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Bibliographic Details
Main Authors: Rowoon Lee, Vitchan Kim, Youngjin Chun, Donghak Kim
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/13/9/1429