Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts
Background: Patients addicted to crack-cocaine routinely have difficulty sustaining treatment, which could be related to dysfunctional cerebral activity that occurs in addiction. Objective: To investigate the indirect electrophysiological effects of single transcranial direct current stimulation (tD...
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doaj-1f7066faab50410ebff5c14058617c072021-03-18T04:37:01ZengElsevierBrain Stimulation1935-861X2014-01-0171130132Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine AddictsCatarine Lima Conti0Ester Miyuki Nakamura-Palacios1Corresponding author. Programa de Pós-Graduação em Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos, 1468, 29.047-105 Vitória, ES, Brazil. Fax: +55 27 3335 7330.; Laboratory of Cognitive Sciences and Neuropsychopharmacology, Program of Post-Graduation in Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, BrazilLaboratory of Cognitive Sciences and Neuropsychopharmacology, Program of Post-Graduation in Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, BrazilBackground: Patients addicted to crack-cocaine routinely have difficulty sustaining treatment, which could be related to dysfunctional cerebral activity that occurs in addiction. Objective: To investigate the indirect electrophysiological effects of single transcranial direct current stimulation (tDCS) on cocaine-addicted brains. Methods: The patients received either left cathodal/right anodal or sham stimulation over the DLPFC. The region of interest was the anterior cingulate cortex (ACC) during the N2 time window (200–350 ms). Event-related potentials in the ACC were measured during visual presentation of crack-related cues or neutral cues. Results: Low-resolution brain electromagnetic tomography (LORETA) indicated that exposure to crack-related images led to increased activity in the ACC in the sham group, while the tDCS group showed decreased ACC activity after visualization of drug cues. Conclusion: Prefrontal tDCS specifically modulated the ACC response during exposure to visual drug cues in crack-cocaine users.http://www.sciencedirect.com/science/article/pii/S1935861X13002891tDCSCrack-cocaine addictionEvent-related potentialDorsolateral prefrontal cortexAnterior cingulate cortex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Catarine Lima Conti Ester Miyuki Nakamura-Palacios |
spellingShingle |
Catarine Lima Conti Ester Miyuki Nakamura-Palacios Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts Brain Stimulation tDCS Crack-cocaine addiction Event-related potential Dorsolateral prefrontal cortex Anterior cingulate cortex |
author_facet |
Catarine Lima Conti Ester Miyuki Nakamura-Palacios |
author_sort |
Catarine Lima Conti |
title |
Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts |
title_short |
Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts |
title_full |
Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts |
title_fullStr |
Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts |
title_full_unstemmed |
Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts |
title_sort |
bilateral transcranial direct current stimulation over dorsolateral prefrontal cortex changes the drug-cued reactivity in the anterior cingulate cortex of crack-cocaine addicts |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2014-01-01 |
description |
Background: Patients addicted to crack-cocaine routinely have difficulty sustaining treatment, which could be related to dysfunctional cerebral activity that occurs in addiction. Objective: To investigate the indirect electrophysiological effects of single transcranial direct current stimulation (tDCS) on cocaine-addicted brains. Methods: The patients received either left cathodal/right anodal or sham stimulation over the DLPFC. The region of interest was the anterior cingulate cortex (ACC) during the N2 time window (200–350 ms). Event-related potentials in the ACC were measured during visual presentation of crack-related cues or neutral cues. Results: Low-resolution brain electromagnetic tomography (LORETA) indicated that exposure to crack-related images led to increased activity in the ACC in the sham group, while the tDCS group showed decreased ACC activity after visualization of drug cues. Conclusion: Prefrontal tDCS specifically modulated the ACC response during exposure to visual drug cues in crack-cocaine users. |
topic |
tDCS Crack-cocaine addiction Event-related potential Dorsolateral prefrontal cortex Anterior cingulate cortex |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X13002891 |
work_keys_str_mv |
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