Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts

Background: Patients addicted to crack-cocaine routinely have difficulty sustaining treatment, which could be related to dysfunctional cerebral activity that occurs in addiction. Objective: To investigate the indirect electrophysiological effects of single transcranial direct current stimulation (tD...

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Main Authors: Catarine Lima Conti, Ester Miyuki Nakamura-Palacios
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Brain Stimulation
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1935861X13002891
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spelling doaj-1f7066faab50410ebff5c14058617c072021-03-18T04:37:01ZengElsevierBrain Stimulation1935-861X2014-01-0171130132Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine AddictsCatarine Lima Conti0Ester Miyuki Nakamura-Palacios1Corresponding author. Programa de Pós-Graduação em Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos, 1468, 29.047-105 Vitória, ES, Brazil. Fax: +55 27 3335 7330.; Laboratory of Cognitive Sciences and Neuropsychopharmacology, Program of Post-Graduation in Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, BrazilLaboratory of Cognitive Sciences and Neuropsychopharmacology, Program of Post-Graduation in Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, BrazilBackground: Patients addicted to crack-cocaine routinely have difficulty sustaining treatment, which could be related to dysfunctional cerebral activity that occurs in addiction. Objective: To investigate the indirect electrophysiological effects of single transcranial direct current stimulation (tDCS) on cocaine-addicted brains. Methods: The patients received either left cathodal/right anodal or sham stimulation over the DLPFC. The region of interest was the anterior cingulate cortex (ACC) during the N2 time window (200–350 ms). Event-related potentials in the ACC were measured during visual presentation of crack-related cues or neutral cues. Results: Low-resolution brain electromagnetic tomography (LORETA) indicated that exposure to crack-related images led to increased activity in the ACC in the sham group, while the tDCS group showed decreased ACC activity after visualization of drug cues. Conclusion: Prefrontal tDCS specifically modulated the ACC response during exposure to visual drug cues in crack-cocaine users.http://www.sciencedirect.com/science/article/pii/S1935861X13002891tDCSCrack-cocaine addictionEvent-related potentialDorsolateral prefrontal cortexAnterior cingulate cortex
collection DOAJ
language English
format Article
sources DOAJ
author Catarine Lima Conti
Ester Miyuki Nakamura-Palacios
spellingShingle Catarine Lima Conti
Ester Miyuki Nakamura-Palacios
Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts
Brain Stimulation
tDCS
Crack-cocaine addiction
Event-related potential
Dorsolateral prefrontal cortex
Anterior cingulate cortex
author_facet Catarine Lima Conti
Ester Miyuki Nakamura-Palacios
author_sort Catarine Lima Conti
title Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts
title_short Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts
title_full Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts
title_fullStr Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts
title_full_unstemmed Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts
title_sort bilateral transcranial direct current stimulation over dorsolateral prefrontal cortex changes the drug-cued reactivity in the anterior cingulate cortex of crack-cocaine addicts
publisher Elsevier
series Brain Stimulation
issn 1935-861X
publishDate 2014-01-01
description Background: Patients addicted to crack-cocaine routinely have difficulty sustaining treatment, which could be related to dysfunctional cerebral activity that occurs in addiction. Objective: To investigate the indirect electrophysiological effects of single transcranial direct current stimulation (tDCS) on cocaine-addicted brains. Methods: The patients received either left cathodal/right anodal or sham stimulation over the DLPFC. The region of interest was the anterior cingulate cortex (ACC) during the N2 time window (200–350 ms). Event-related potentials in the ACC were measured during visual presentation of crack-related cues or neutral cues. Results: Low-resolution brain electromagnetic tomography (LORETA) indicated that exposure to crack-related images led to increased activity in the ACC in the sham group, while the tDCS group showed decreased ACC activity after visualization of drug cues. Conclusion: Prefrontal tDCS specifically modulated the ACC response during exposure to visual drug cues in crack-cocaine users.
topic tDCS
Crack-cocaine addiction
Event-related potential
Dorsolateral prefrontal cortex
Anterior cingulate cortex
url http://www.sciencedirect.com/science/article/pii/S1935861X13002891
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