Crystal structure of a nucleoside model for the interstrand cross-link formed by the reaction of 2′-deoxyguanosine and an abasic site in duplex DNA

Crystal structure of a nucleoside model for the interstrand cross-link formed by the reaction of 2′-deoxyguanosine and an abasic site in duplex DNA

The title compound, 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-{[(2R,4S,5R)-4-methoxy-5-(methoxymethyl)tetrahydrofuran-2-yl]amino}-1H-purin-6(9H)-one, C17H25N5O7, crystallizes with two independent molecules (A and B) in the asymmetric unit. In the crystal, the guanosine moietie...

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Bibliographic Details
Main Authors: Michael J. Catalano, Kasi Viswanatharaju Ruddraraju, Charles L. Barnes, Kent S. Gates
Format: Article
Language:English
Published: International Union of Crystallography 2016-05-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
crystal structure
purine-6(9H)-one
2′-deoxyguanosine
deoxy-D-ribofuranose
glycosidic linkage
nucleobase
hydrogen bonding
Online Access:http://scripts.iucr.org/cgi-bin/paper?S205698901600517X

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