Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus

Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus

In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureusΔmvaS mutant can revert to prototrophy. This mutant couldn’t grow in the absence of MVA. However, after a long lag-phase of 4–6 days the mutant adapted from auxotrophic to prototrophic phenotype. During t...

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Bibliographic Details
Main Authors: Sebastian Reichert, Patrick Ebner, Eve-Julie Bonetti, Arif Luqman, Mulugeta Nega, Jacques Schrenzel, Cathrin Spröer, Boyke Bunk, Jörg Overmann, Peter Sass, Patrice François, Friedrich Götz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
adaptation
mutation
mevalonate pathway
isoprenoids
lactonase
Drp35
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01539/full

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