Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides

ADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synth...

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Main Authors:	Anlian Zhu, Xin Li, Lili Bai, Gongming Zhu, Yuanyang Guo, Jianwei Lin, Yiwen Cui, Gaofei Tian, Lihe Zhang, Jianji Wang, Xiang David Li, Lingjun Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19409-1

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spelling	doaj-1f3c4c9b9d4d4c23b09e955f0979915c2021-05-11T08:55:37ZengNature Publishing GroupNature Communications2041-17232020-11-011111910.1038/s41467-020-19409-1Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptidesAnlian Zhu0Xin Li1Lili Bai2Gongming Zhu3Yuanyang Guo4Jianwei Lin5Yiwen Cui6Gaofei Tian7Lihe Zhang8Jianji Wang9Xiang David Li10Lingjun Li11Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal UniversityDepartment of Chemistry, The University of Hong KongHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal UniversityHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal UniversityHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal UniversityDepartment of Chemistry, The University of Hong KongDepartment of Chemistry, The University of Hong KongDepartment of Chemistry, The University of Hong KongState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking UniversityHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal UniversityDepartment of Chemistry, The University of Hong KongHenan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal UniversityADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synthesis of α-ADP-ribosylated peptides.https://doi.org/10.1038/s41467-020-19409-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anlian Zhu Xin Li Lili Bai Gongming Zhu Yuanyang Guo Jianwei Lin Yiwen Cui Gaofei Tian Lihe Zhang Jianji Wang Xiang David Li Lingjun Li
spellingShingle	Anlian Zhu Xin Li Lili Bai Gongming Zhu Yuanyang Guo Jianwei Lin Yiwen Cui Gaofei Tian Lihe Zhang Jianji Wang Xiang David Li Lingjun Li Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides Nature Communications
author_facet	Anlian Zhu Xin Li Lili Bai Gongming Zhu Yuanyang Guo Jianwei Lin Yiwen Cui Gaofei Tian Lihe Zhang Jianji Wang Xiang David Li Lingjun Li
author_sort	Anlian Zhu
title	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_short	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_full	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_fullStr	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_full_unstemmed	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_sort	biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important adp-ribosylated peptides
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-11-01
description	ADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synthesis of α-ADP-ribosylated peptides.
url	https://doi.org/10.1038/s41467-020-19409-1
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Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides

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