Axonal and synaptic failure suppress the transfer of firing rate oscillations, synchrony and information during high frequency deep brain stimulation

Axonal and synaptic failure suppress the transfer of firing rate oscillations, synchrony and information during high frequency deep brain stimulation

High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a widely used treatment for Parkinson's disease, but its effects on neural activity in basal ganglia circuits are not fully understood. DBS increases the excitation of STN efferents yet decouples STN spiking pattern...

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Bibliographic Details
Main Authors: Robert Rosenbaum, Andrew Zimnik, Fang Zheng, Robert S. Turner, Christian Alzheimer, Brent Doiron, Jonathan E. Rubin
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Deep brain stimulation
Axonal failure
Synaptic failure
Short term depression
Beta oscillations
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002519

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http://www.sciencedirect.com/science/article/pii/S0969996113002519

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