Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS

Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS

Exenatide is the first approved glucagon-like peptide 1 receptor agonist subcutaneously or intramuscularly injected for the treatment of type 2 diabetes mellitus. Typical therapeutic plasma concentrations are in the low pg/mL range, therefore requiring ultra-sensitive quantification. To enable the a...

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Bibliographic Details
Main Authors: Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. Haefeli
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Exenatide
Nasal
Intravenous
UPLC
Tandem mass spectrometry
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177919310895

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