Cells isolated from residual intracranial tumors after treatment express iPSC genes and possess neural lineage differentiation plasticityResearch in context

Background: The goal of this study is to identify and characterize treatment resistant tumor initiating cells (TRTICs) using orthotopic xenografts. Methods: TRTICs were enriched from GBM cell lines using mouse xenografts treated with fractionated doses of radiation and temozolomide. TRTICs were char...

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Bibliographic Details
Main Authors: Kamalakannan Palanichamy, John R. Jacob, Kevin T. Litzenberg, Abhik Ray-Chaudhury, Arnab Chakravarti
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418303773

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