Cells isolated from residual intracranial tumors after treatment express iPSC genes and possess neural lineage differentiation plasticityResearch in context
Background: The goal of this study is to identify and characterize treatment resistant tumor initiating cells (TRTICs) using orthotopic xenografts. Methods: TRTICs were enriched from GBM cell lines using mouse xenografts treated with fractionated doses of radiation and temozolomide. TRTICs were char...
Main Authors: | Kamalakannan Palanichamy, John R. Jacob, Kevin T. Litzenberg, Abhik Ray-Chaudhury, Arnab Chakravarti |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2018-10-01
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Series: | EBioMedicine |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396418303773 |
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