Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases

Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases

Epigenetic mechanisms, especially DNA methylation and histone modifications, are dynamic processes that regulate the gene expression transcriptional program in normal and diseased states. The bromodomain and extraterminal (BET) protein family (BRD2, BRD3, BRD4, and BRDT) are epigenetic readers that,...

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Bibliographic Details
Main Authors: Jose Luis Morgado-Pascual, Sandra Rayego-Mateos, Lucia Tejedor, Beatriz Suarez-Alvarez, Marta Ruiz-Ortega
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
BET proteins
renal injury
inflammation
fibrosis
chronic kidney disease
epigenetic modifications
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01315/full

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