Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats

Abstract A better understanding of the secondary injury mechanisms that occur after traumatic spinal cord injury (SCI) is essential for the development of novel neuroprotective strategies linked to the restoration of metabolic deficits. We and others have shown that Ketogenic diet (KD), a high fat,...

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Bibliographic Details
Main Authors: Oscar Seira, Kathleen Kolehmainen, Jie Liu, Femke Streijger, Anne Haegert, Stéphane Lebihan, Robert Boushel, Wolfram Tetzlaff
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96003-5