Upconversion nanoparticles: on the way from diagnostics to theranostics

Upconversion nanoparticles: on the way from diagnostics to theranostics

We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF4 codoped with Yb3+ and Er3+or Tm3+. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs...

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Main Authors: Generalova Alla, Mironova Kristina, Sholina Natalya, Rocheva Vasylina, Nechaev Andrey, Grebenik Ekaterina, Guller Anna, Zvyagin Andrey, Deyev Sergey, Zubov Vitaly, Khaydukov Evgeny
Format: Article
Language:English
Published: EDP Sciences 2018-01-01
Series:EPJ Web of Conferences
Online Access:https://doi.org/10.1051/epjconf/201819003001
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spelling doaj-1efa1f849a5d433394ad3fc3a2b14e952021-08-02T08:21:47ZengEDP SciencesEPJ Web of Conferences2100-014X2018-01-011900300110.1051/epjconf/201819003001epjconf_hbsm2018_03001Upconversion nanoparticles: on the way from diagnostics to theranosticsGeneralova AllaMironova KristinaSholina Natalya0Rocheva Vasylina1Nechaev Andrey2Grebenik EkaterinaGuller Anna3Zvyagin Andrey4Deyev Sergey5Zubov Vitaly6Khaydukov EvgenySechenov First Moscow State Medical UniversityScientific Research Centre “Crystallography and Photonics” RASInstitute of Fine Chemical TechnologiesMacquarie UniversityMacquarie UniversityShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RASShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RASWe report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF4 codoped with Yb3+ and Er3+or Tm3+. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue “transparency window”, as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility of the hybrid UCNPs was demonstrated for in vitro bioassay and in vivo optical whole animal imaging using a home-built epiluminescence imaging system.https://doi.org/10.1051/epjconf/201819003001
collection DOAJ
language English
format Article
sources DOAJ
author Generalova Alla
Mironova Kristina
Sholina Natalya
Rocheva Vasylina
Nechaev Andrey
Grebenik Ekaterina
Guller Anna
Zvyagin Andrey
Deyev Sergey
Zubov Vitaly
Khaydukov Evgeny
spellingShingle Generalova Alla
Mironova Kristina
Sholina Natalya
Rocheva Vasylina
Nechaev Andrey
Grebenik Ekaterina
Guller Anna
Zvyagin Andrey
Deyev Sergey
Zubov Vitaly
Khaydukov Evgeny
Upconversion nanoparticles: on the way from diagnostics to theranostics
EPJ Web of Conferences
author_facet Generalova Alla
Mironova Kristina
Sholina Natalya
Rocheva Vasylina
Nechaev Andrey
Grebenik Ekaterina
Guller Anna
Zvyagin Andrey
Deyev Sergey
Zubov Vitaly
Khaydukov Evgeny
author_sort Generalova Alla
title Upconversion nanoparticles: on the way from diagnostics to theranostics
title_short Upconversion nanoparticles: on the way from diagnostics to theranostics
title_full Upconversion nanoparticles: on the way from diagnostics to theranostics
title_fullStr Upconversion nanoparticles: on the way from diagnostics to theranostics
title_full_unstemmed Upconversion nanoparticles: on the way from diagnostics to theranostics
title_sort upconversion nanoparticles: on the way from diagnostics to theranostics
publisher EDP Sciences
series EPJ Web of Conferences
issn 2100-014X
publishDate 2018-01-01
description We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF4 codoped with Yb3+ and Er3+or Tm3+. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue “transparency window”, as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility of the hybrid UCNPs was demonstrated for in vitro bioassay and in vivo optical whole animal imaging using a home-built epiluminescence imaging system.
url https://doi.org/10.1051/epjconf/201819003001
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