Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity

Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity

The circularized bacteriocin enterocin AS-48 produced by Enterococcus sp. exhibits antibacterial activity through membrane disruption. The membrane-penetrating activity of enterocin AS-48 has been attributed to a specific alpha-helical region on the circular peptide. Truncated, linearized forms cont...

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Bibliographic Details
Main Authors: Jessica N. Ross, Francisco R. Fields, Veronica R. Kalwajtys, Alejandro J. Gonzalez, Samantha O’Connor, Angela Zhang, Thomas E. Moran, Daniel E. Hammers, Katelyn E. Carothers, Shaun W. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
bacteriocin
antimicrobial peptide
enterocin
synthetic peptide
antibiotics
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.589666/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.589666/full

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