A high-content small molecule screen identifies novel inducers of definitive endoderm

A high-content small molecule screen identifies novel inducers of definitive endoderm

Objectives: Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can generate any given cell type in the human body. One challenge for cell-replacement therapy is the efficient differentiation and expansion of large quantities of progenitor cells from pluripotent stem...

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Bibliographic Details
Main Authors: Alexander Korostylev, Pallavi U. Mahaddalkar, Oliver Keminer, Kamyar Hadian, Kenji Schorpp, Philip Gribbon, Heiko Lickert
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Molecular Metabolism
Subjects:
Rock inhibition
Fasudil
Pancreatic progenitors
Anterior definitive endoderm
Differentiations
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817301369

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http://www.sciencedirect.com/science/article/pii/S2212877817301369

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