Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with cal...

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Main Authors: Myat Nyan, Daisuke Sato, Mitsumasa Oda, Tetsu Machida, Hiroshi Kobayashi, Takahiro Nakamura, Shohei Kasugai
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319342379
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spelling doaj-1ef4c9dd422f4d90adb97e8833902e102020-11-25T02:20:48ZengElsevierJournal of Pharmacological Sciences1347-86132007-01-011044384386Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial DefectMyat Nyan0Daisuke Sato1Mitsumasa Oda2Tetsu Machida3Hiroshi Kobayashi4Takahiro Nakamura5Shohei Kasugai6Oral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Corresponding author. myatnyan@gmail.comOral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, JapanOral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, JapanOral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, JapanOral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, JapanOral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, JapanOral Implantology and Regenerative Dental Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, JapanSimvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with calcium sulfate or with combination of 1 mg simvastatin and calcium sulfate. In the combination group, although the least amount of bone formation with intense soft tissue inflammation was observed at 2 and 4 weeks, remarkable bone formation was evident at 8 weeks. Conclusively, the combination of simvastatin and calcium sulfate stimulated bone regeneration in spite of the inflammatory response. Keywords:: simvastatin, calcium sulfate, bone formationhttp://www.sciencedirect.com/science/article/pii/S1347861319342379
collection DOAJ
language English
format Article
sources DOAJ
author Myat Nyan
Daisuke Sato
Mitsumasa Oda
Tetsu Machida
Hiroshi Kobayashi
Takahiro Nakamura
Shohei Kasugai
spellingShingle Myat Nyan
Daisuke Sato
Mitsumasa Oda
Tetsu Machida
Hiroshi Kobayashi
Takahiro Nakamura
Shohei Kasugai
Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect
Journal of Pharmacological Sciences
author_facet Myat Nyan
Daisuke Sato
Mitsumasa Oda
Tetsu Machida
Hiroshi Kobayashi
Takahiro Nakamura
Shohei Kasugai
author_sort Myat Nyan
title Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect
title_short Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect
title_full Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect
title_fullStr Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect
title_full_unstemmed Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect
title_sort bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2007-01-01
description Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with calcium sulfate or with combination of 1 mg simvastatin and calcium sulfate. In the combination group, although the least amount of bone formation with intense soft tissue inflammation was observed at 2 and 4 weeks, remarkable bone formation was evident at 8 weeks. Conclusively, the combination of simvastatin and calcium sulfate stimulated bone regeneration in spite of the inflammatory response. Keywords:: simvastatin, calcium sulfate, bone formation
url http://www.sciencedirect.com/science/article/pii/S1347861319342379
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