Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis

Corneal epithelium shares similar molecular signatures to other stratified epithelia. Here, the authors map super-enhancers and accessible chromatin in corneal epithelium, identifying a transcription regulatory circuit, including RUNX1, PAX6, and SMAD3, required for corneal epithelial identity and h...

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Main Authors:	Mingsen Li, Huaxing Huang, Lingyu Li, Chenxi He, Liqiong Zhu, Huizhen Guo, Li Wang, Jiafeng Liu, Siqi Wu, Jingxin Liu, Tao Xu, Zhen Mao, Nan Cao, Kang Zhang, Fei Lan, Junjun Ding, Jin Yuan, Yizhi Liu, Hong Ouyang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20713-z

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spelling	doaj-1ef2ff68b9834f349529dd426ea394f72021-01-24T12:11:54ZengNature Publishing GroupNature Communications2041-17232021-01-0112111410.1038/s41467-020-20713-zCore transcription regulatory circuitry orchestrates corneal epithelial homeostasisMingsen Li0Huaxing Huang1Lingyu Li2Chenxi He3Liqiong Zhu4Huizhen Guo5Li Wang6Jiafeng Liu7Siqi Wu8Jingxin Liu9Tao Xu10Zhen Mao11Nan Cao12Kang Zhang13Fei Lan14Junjun Ding15Jin Yuan16Yizhi Liu17Hong Ouyang18State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityKey Laboratory of Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences; Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityProgram of Stem Cells and Regenerative Medicine, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityKey Laboratory of Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences; Liver Cancer Institute, Zhongshan Hospital, Fudan UniversityCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityCorneal epithelium shares similar molecular signatures to other stratified epithelia. Here, the authors map super-enhancers and accessible chromatin in corneal epithelium, identifying a transcription regulatory circuit, including RUNX1, PAX6, and SMAD3, required for corneal epithelial identity and homeostasis.https://doi.org/10.1038/s41467-020-20713-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mingsen Li Huaxing Huang Lingyu Li Chenxi He Liqiong Zhu Huizhen Guo Li Wang Jiafeng Liu Siqi Wu Jingxin Liu Tao Xu Zhen Mao Nan Cao Kang Zhang Fei Lan Junjun Ding Jin Yuan Yizhi Liu Hong Ouyang
spellingShingle	Mingsen Li Huaxing Huang Lingyu Li Chenxi He Liqiong Zhu Huizhen Guo Li Wang Jiafeng Liu Siqi Wu Jingxin Liu Tao Xu Zhen Mao Nan Cao Kang Zhang Fei Lan Junjun Ding Jin Yuan Yizhi Liu Hong Ouyang Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis Nature Communications
author_facet	Mingsen Li Huaxing Huang Lingyu Li Chenxi He Liqiong Zhu Huizhen Guo Li Wang Jiafeng Liu Siqi Wu Jingxin Liu Tao Xu Zhen Mao Nan Cao Kang Zhang Fei Lan Junjun Ding Jin Yuan Yizhi Liu Hong Ouyang
author_sort	Mingsen Li
title	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_short	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_full	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_fullStr	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_full_unstemmed	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_sort	core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	Corneal epithelium shares similar molecular signatures to other stratified epithelia. Here, the authors map super-enhancers and accessible chromatin in corneal epithelium, identifying a transcription regulatory circuit, including RUNX1, PAX6, and SMAD3, required for corneal epithelial identity and homeostasis.
url	https://doi.org/10.1038/s41467-020-20713-z
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Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis

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