Why Do CD8 + T Cells Become Indifferent To Tumors: A Dynamic Modeling Approach

Why Do CD8 + T Cells Become Indifferent To Tumors: A Dynamic Modeling Approach

CD8+ T cells have the potential to influence the outcome of cancer pathogenesis, including complete tumor eradication or selection of malignant tumor escape variants. The Simian virus 40 large T-antigen oncoprotein promotes tumor formation in T-antigen transgenic mice and also provides multiple tar...

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Bibliographic Details
Main Authors: Colin eCampbell, Ranran eZhang, Jeremy Scott Haley, Xin eLiu, Thomas eLoughran, Todd eSchell, Reka eAlbert, Juilee eThakar
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Physiology
Subjects:
tumor
CD8+ T cells
apoptosis and proliferation rates
dynamic model
T-antigen
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00032/full

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