A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia

A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia

Abstract Background Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies due to sophisticated genetic mutations and epigenetic dysregulation. MicroRNAs (miRNAs), a class of small non-coding RNAs, are important regulators of gene expression in all biological processes,...

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Bibliographic Details
Main Authors: Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen, Shenmeng Gao
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
miR-375
HOXB3
DNMT3B
DNA hypermethylation
AML
Online Access:http://link.springer.com/article/10.1186/s12885-018-4097-z

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http://link.springer.com/article/10.1186/s12885-018-4097-z

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