p60-S6K1 represents a novel kinase active isoform with the mode of regulation distinct from p70/p85-S6K1 isoforms

p60-S6K1 represents a novel kinase active isoform with the mode of regulation distinct from p70/p85-S6K1 isoforms

The phosphatidylinositol-3-kinase (PI3K)/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls plenty of cellular functions regulating phosphorylation one of its mediators ribosomal protein S6 kinase 1 (S6K1). Alternative translation of the common S6K1 transcript can generate...

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Bibliographic Details
Main Authors: I. V. Zaiets, V. V. Holiar, A. S. Sivchenko, V. V. Smialkovska, V. V. Filonenko
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2019-08-01
Series:Ukrainian Biochemical Journal
Subjects:
kinase activity
p60-S6 kinase 1 (p60-S6K1)
PI3K/mTORC1 signaling pathway
regulation by protein phosphorylation
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2019/06/Zaiets_4_19.pdf

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http://ukrbiochemjournal.org/wp-content/uploads/2019/06/Zaiets_4_19.pdf

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