Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity
While a number of therapeutic options to control the progression of human immunodeficiency virus (HIV-1) now exist, a broadly effective preventive vaccine is still not available. Through detailed structural analysis of antibodies able to induce potent effector cell activity, a number of Env epitopes...
Main Authors: | William D. Tolbert, Rebekah T. Sherburn, Verna Van, Marzena Pazgier |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-01-01
|
Series: | Viruses |
Subjects: | |
Online Access: | http://www.mdpi.com/1999-4915/11/1/69 |
Similar Items
-
Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region
by: Maria L. Visciano, et al.
Published: (2019-04-01) -
Effects of gp120 Inner Domain (ID2) Immunogen Doses on Elicitation of Anti-HIV-1 Functional Fc-Effector Response to C1/C2 (Cluster A) Epitopes in Mice
by: Rebekah Sherburn, et al.
Published: (2020-09-01) -
Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions
by: Rebekah Sherburn, et al.
Published: (2021-08-01) -
Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site
by: William D. Tolbert, et al.
Published: (2020-07-01) -
The first structure of HIV-1 gp120 with CD4 and CCR5 receptors
by: Yongjun Guan
Published: (2019-01-01)