Cell-Based Reporter Release Assay to Determine the Activity of Calcium-Dependent Neurotoxins and Neuroactive Pharmaceuticals

The suitability of a newly developed cell-based functional assay was tested for the detection of the activity of a range of neurotoxins and neuroactive pharmaceuticals which act by stimulation or inhibition of calcium-dependent neurotransmitter release. In this functional assay, a reporter enzyme is...

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Bibliographic Details
Main Authors: Andrea Pathe-Neuschäfer-Rube, Frank Neuschäfer-Rube, Gerhard P. Püschel
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/13/4/247