The relationship between malignant biological molecule expression during the pathological process of gastric cancer and helicobacter pylori infection

• Main Author: Shun-Qing Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Gastric cancer Helicobacter pylori Proliferation Invasion
• Online Access: http://www.hnykdxxb.com/PDF/201708/28.pdf

Objective: To study the relationship between malignant biological molecule expression during the pathological process of gastric cancer and helicobacter pylori (HP) infection. Methods: A total of 78 cases of gastric cancer specimens that were surgically removed in our hospital between May 2013 and June 2015 were selected as the research material, the gastric cancer tissue and the tissue adjacent to carcinoma were collected, rapid urease test kits were used to test HP, and fluorescent quantitative PCR kits were used to determine the mRNA expression of proliferation- and invasion-related genes. Results: EZH2, c-myc, PIK3CD, Vav3 and UHRF1 mRNA expression in gastric cancer tissue were significantly higher than those in the tissue adjacent to carcinoma while Mst1, ING5, RASAL and E-cadherin mRNA expression were significantly lower than those in the tissue adjacent to carcinoma; EZH2, c-myc, PIK3CD, Vav3 and UHRF1 mRNA expression in HP-positive gastric cancer tissue were significantly higher than those in HP-negative gastric cancer tissue while Mst1, ING5, RASAL and E-cadherin mRNA expression were significantly lower than those in HP-negative gastric cancer tissue. Conclusion: Helicobacter pylori have regulating effect on the expression of proliferation- and invasion-related malignant biological molecules during the pathological process of gastric cancer.