Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.

Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.

The critical concentration (CC) for ethambutol testing on the Bactec MGIT 960 M. tuberculosis susceptibility testing has been questioned in recent publications. In this study, we correlate susceptibility results from the Bactec 460, MGIT 960 and embB gene sequencing to determine if the Bactec MGIT 9...

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Main Authors: Sara Christianson, Dylan Voth, Joyce Wolfe, Meenu K Sharma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4178229?pdf=render
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spelling doaj-1ebdcaf21c634ebf89341969309b3d732020-11-24T21:50:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10891110.1371/journal.pone.0108911Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.Sara ChristiansonDylan VothJoyce WolfeMeenu K SharmaThe critical concentration (CC) for ethambutol testing on the Bactec MGIT 960 M. tuberculosis susceptibility testing has been questioned in recent publications. In this study, we correlate susceptibility results from the Bactec 460, MGIT 960 and embB gene sequencing to determine if the Bactec MGIT 960 adequately detects ethambutol resistance. We discovered discrepancies between the methods that highlight a need to re-evaluate ethambutol susceptibility testing recommendations, namely by considering lowering currently recommended CC on the MGIT 960. Further studies on the clinical significance of low-level ethambutol resistance are also required.http://europepmc.org/articles/PMC4178229?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Sara Christianson
Dylan Voth
Joyce Wolfe
Meenu K Sharma
spellingShingle Sara Christianson
Dylan Voth
Joyce Wolfe
Meenu K Sharma
Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.
PLoS ONE
author_facet Sara Christianson
Dylan Voth
Joyce Wolfe
Meenu K Sharma
author_sort Sara Christianson
title Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.
title_short Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.
title_full Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.
title_fullStr Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.
title_full_unstemmed Re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the MGIT 960.
title_sort re-evaluation of the critical concentration for ethambutol antimicrobial sensitivity testing on the mgit 960.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description The critical concentration (CC) for ethambutol testing on the Bactec MGIT 960 M. tuberculosis susceptibility testing has been questioned in recent publications. In this study, we correlate susceptibility results from the Bactec 460, MGIT 960 and embB gene sequencing to determine if the Bactec MGIT 960 adequately detects ethambutol resistance. We discovered discrepancies between the methods that highlight a need to re-evaluate ethambutol susceptibility testing recommendations, namely by considering lowering currently recommended CC on the MGIT 960. Further studies on the clinical significance of low-level ethambutol resistance are also required.
url http://europepmc.org/articles/PMC4178229?pdf=render
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AT dylanvoth reevaluationofthecriticalconcentrationforethambutolantimicrobialsensitivitytestingonthemgit960
AT joycewolfe reevaluationofthecriticalconcentrationforethambutolantimicrobialsensitivitytestingonthemgit960
AT meenuksharma reevaluationofthecriticalconcentrationforethambutolantimicrobialsensitivitytestingonthemgit960
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