Near-infrared reflectance bull’s eye maculopathy as an early indication of hydroxychloroquine toxicity

• Main Authors: Wong KL, Pautler SE, Browning DJ
• Format: Article
• Language: English
• Published: Dove Medical Press 2015-03-01
• Series: Clinical Ophthalmology
• Online Access: http://www.dovepress.com/near-infrared-reflectance-bullrsquos-eye-maculopathy-as-an-early-indic-peer-reviewed-article-OPTH

Keye L Wong,1 Scott E Pautler,2 David J Browning31Retina Associates of Sarasota, Sarasota, FL, USA; 2Retina Vitreous Associates of Florida, Tampa, FL, USA; 3Charlotte Eye Ear Nose and Throat Associates, Charlotte, NC, USAImportance: In some patients, hydroxychloroquine ocular toxicity may progress even following cessation of therapy. Any leverage the clinician may use to allow earlier detection may avert significant vision loss.Observation: We report three cases suggesting that bull’s eye maculopathy seen on near-infrared reflectance with a confocal scanning laser ophthalmoscope could be an early, objective manifestation of hydroxychloroquine ocular toxicity, and with progression of the disease this near-infrared “bull’s eye” change may disappear.Conclusion and relevance: Alerting clinicians to this observation may allow a larger case series to corroborate the hypothesis that bull’s eye maculopathy detected by near-infrared reflectance may represent an early sign of hydroxychloroquine toxicity.Keywords: confocal, scanning laser ophthalmoscope, multifocal ERG