Comparison of the hyper-cvad with an institutional regimen for the treatment of acute lymphoblastic leukemia in adults in a hospital of Mexico

• Main Authors: Christian Omar Ramos-Peñafiel, Álvaro Cabrera-García, Etta Rozen-Fuller, Guadalupe González-León, Carolina Balderas, Juan Julio Kassack-Ipiña, Humberto Castellanos-Sinco, Carlos Martínez-Murillo, Efreen Montaño-Figueroa, Adolfo Martínez-Tovar, Irma Olarte-Carrillo, Adrián Santoyo-Sánchez, Juan Collazo-Jaloma
• Format: Article
• Language: Spanish
• Published: Instituto Nacional de Salud 2014-09-01
• Series: Revista Peruana de Medicina Experimental y Salud Pública
• Subjects: leucemia linfoblástica; protocolos de quimioterapia combinada antineoplásica; adulto
• Online Access: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/91

In order to assess the mortality and toxicity of the Hyper-CVAD protocol used as first-line treatment of acute lymphoblastic leukemia, a retrospective cohort study was performed in patients less than 40 years of age from March to September 2011 treated with Hyper-CVAD regimen. Mortality and toxicity was compared with the results of patients treated with the institutional HGMLAL07 regimen between 2009-2012. 18 patients were included; the median age was 26 years old. Complete remissions (67.7% versus 81.9%) as well as one-year (40% versus 62%) and 2 year survival rates (18% versus 34%) were lower with the Hyper-CVAD regimen. By selecting only patients younger than 35 years, the effectiveness of Hyper-CVAD was also lower. In our experience and because of its high cost and toxicity, the Hyper-CVAD regimen should be limited to patients with relapsed or refractory leukemia.