Evidence for the possible biological significance of the igf-1 gene alternative splicing in prostate cancer

Evidence for the possible biological significance of the igf-1 gene alternative splicing in prostate cancer

Insulin-like growth factor I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF receptor (IGF-IR), however IGF-I signaling vi...

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Bibliographic Details
Main Authors: Anastassios ePhilippou, Athanasios eArmakolas, Michael ekoutsilieris
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Endocrinology
Subjects:
Apoptosis
Cell Survival
Cancer Progression
human IGF-I isoforms
IGF-I bioactivity
IGF-I peptides
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00031/full

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