Regulation of autophagy during mitosis

Regulation of autophagy during mitosis

Based on observations of mitosis process, it has been implied that autophagy is repressed. Because the integrity of chromosomes and proteins are significant for cell cycle, the repression of autophagy serves as a protection. However, the mechanistic detail of whether and how autophagy is regulated d...

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Main Author: Gong Yikang
Format: Article
Language:English
Published: EDP Sciences 2021-01-01
Series:E3S Web of Conferences
Online Access:https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/47/e3sconf_icepe2021_03051.pdf
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spelling doaj-1ea3148e8d9746f48db0273b67bb642e2021-06-18T08:19:52ZengEDP SciencesE3S Web of Conferences2267-12422021-01-012710305110.1051/e3sconf/202127103051e3sconf_icepe2021_03051Regulation of autophagy during mitosisGong Yikang0College of Nature Science, University of Massachusetts AmherstBased on observations of mitosis process, it has been implied that autophagy is repressed. Because the integrity of chromosomes and proteins are significant for cell cycle, the repression of autophagy serves as a protection. However, the mechanistic detail of whether and how autophagy is regulated during mitosis remains controversial. In this review, we aim to analyse and review the recent literature on the regulation of autophagy during mitosis. According to researches, autophagy is repressed via inhibitory phosphorylation of autophagy genes by CDK1, CUL4-RING ubiquitin ligases-mediated and WIPI2 polyubiquitination and proteasomal degradation. In addition, the recent evidence that indicates autophagy is repressed will be reviewed.https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/47/e3sconf_icepe2021_03051.pdf
collection DOAJ
language English
format Article
sources DOAJ
author Gong Yikang
spellingShingle Gong Yikang
Regulation of autophagy during mitosis
E3S Web of Conferences
author_facet Gong Yikang
author_sort Gong Yikang
title Regulation of autophagy during mitosis
title_short Regulation of autophagy during mitosis
title_full Regulation of autophagy during mitosis
title_fullStr Regulation of autophagy during mitosis
title_full_unstemmed Regulation of autophagy during mitosis
title_sort regulation of autophagy during mitosis
publisher EDP Sciences
series E3S Web of Conferences
issn 2267-1242
publishDate 2021-01-01
description Based on observations of mitosis process, it has been implied that autophagy is repressed. Because the integrity of chromosomes and proteins are significant for cell cycle, the repression of autophagy serves as a protection. However, the mechanistic detail of whether and how autophagy is regulated during mitosis remains controversial. In this review, we aim to analyse and review the recent literature on the regulation of autophagy during mitosis. According to researches, autophagy is repressed via inhibitory phosphorylation of autophagy genes by CDK1, CUL4-RING ubiquitin ligases-mediated and WIPI2 polyubiquitination and proteasomal degradation. In addition, the recent evidence that indicates autophagy is repressed will be reviewed.
url https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/47/e3sconf_icepe2021_03051.pdf
work_keys_str_mv AT gongyikang regulationofautophagyduringmitosis
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