Using Aptamers for Cancer Biomarker Discovery

Using Aptamers for Cancer Biomarker Discovery

Aptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules. Aptamers have high affinity and high specificity that are comparable to that of antibodies. They are obtained using it...

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Bibliographic Details
Main Authors: Yun Min Chang, Michael J. Donovan, Weihong Tan
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.1155/2013/817350
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spelling doaj-1e9a165f22d841ec96fd3a77cc6cb0002020-11-24T23:57:31ZengHindawi LimitedJournal of Nucleic Acids2090-02012090-021X2013-01-01201310.1155/2013/817350817350Using Aptamers for Cancer Biomarker DiscoveryYun Min Chang0Michael J. Donovan1Weihong Tan2Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USAMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, 410082, ChinaCenter for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USAAptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules. Aptamers have high affinity and high specificity that are comparable to that of antibodies. They are obtained using iterative method, called (Systematic Evolution of Ligands by Exponential Enrichment) SELEX and cell-based SELEX (cell-SELEX). Aptamers can be paired with recent advances in nanotechnology, microarray, microfluidics, and other technologies for applications in clinical medicine. One particular area that aptamers can shed a light on is biomarker discovery. Biomarkers are important in diagnosis and treatment of cancer. In this paper, we will describe ways in which aptamers can be used to discover biomarkers for cancer diagnosis and therapeutics.http://dx.doi.org/10.1155/2013/817350
collection DOAJ
language English
format Article
sources DOAJ
author Yun Min Chang
Michael J. Donovan
Weihong Tan
spellingShingle Yun Min Chang
Michael J. Donovan
Weihong Tan
Using Aptamers for Cancer Biomarker Discovery
Journal of Nucleic Acids
author_facet Yun Min Chang
Michael J. Donovan
Weihong Tan
author_sort Yun Min Chang
title Using Aptamers for Cancer Biomarker Discovery
title_short Using Aptamers for Cancer Biomarker Discovery
title_full Using Aptamers for Cancer Biomarker Discovery
title_fullStr Using Aptamers for Cancer Biomarker Discovery
title_full_unstemmed Using Aptamers for Cancer Biomarker Discovery
title_sort using aptamers for cancer biomarker discovery
publisher Hindawi Limited
series Journal of Nucleic Acids
issn 2090-0201
2090-021X
publishDate 2013-01-01
description Aptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules. Aptamers have high affinity and high specificity that are comparable to that of antibodies. They are obtained using iterative method, called (Systematic Evolution of Ligands by Exponential Enrichment) SELEX and cell-based SELEX (cell-SELEX). Aptamers can be paired with recent advances in nanotechnology, microarray, microfluidics, and other technologies for applications in clinical medicine. One particular area that aptamers can shed a light on is biomarker discovery. Biomarkers are important in diagnosis and treatment of cancer. In this paper, we will describe ways in which aptamers can be used to discover biomarkers for cancer diagnosis and therapeutics.
url http://dx.doi.org/10.1155/2013/817350
work_keys_str_mv AT yunminchang usingaptamersforcancerbiomarkerdiscovery
AT michaeljdonovan usingaptamersforcancerbiomarkerdiscovery
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